Which API features don't work on .NET 4.8.1 (because they rely on .NET 6 and thus will not be fully supportable after 12 Nov)

Is it better to stick with cBots that can be rebuilt for .NET Framework, even if that means disabling some parts (but which?), with support for .NET 6 ending soon and Microsoft saying:

“.NET Framework 4.8.1 is the latest version of .NET Framework and will continue to be distributed with future releases of Windows. As long as it is installed on a supported version of Windows, .NET Framework 4.8.1 will continue to also be supported.” at https://dotnet.microsoft.com/en-us/platform/support/policy/dotnet-framework .

Other sites https://blog.inedo.com/dotnet/demystifying-lts/ back this up: “.NET Framework 4.8: Support is now tied to the operating system it’s installed on, and will be supported indefinitely, well beyond the next ten years” 

Whilst Microsoft's idea of "LTS Long Term Support" seems somewhat short at 3 years we're stuck with it.
(for comparison, IBM now support their mainframe z/OS software for 5 years https://www.topgun-tech.com/end-of-service-life/ibm/zos/ )